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Details of Brad Moore, Ph.D.
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Ph.D. 1994, University of Washington
Bioorganic Chemistry Dr. Brad Moore has a joint appointment with the Skaggs School of Pharmacy and Pharmaceutical Sciences and Scripps Institute of Oceanography, as Professor. Dr. Moore received his Ph.D. in Bioorganic Chemistry from the University of Washington in 1994. His research is focused on developing new technologies to genetically engineer pharmaceutically relevant bacterial natural products and their derivatives for drug discovery and development. Research Interests: Biosynthesis of marine microbial natural products, combinatorial biosynthesis, in vitro and in vivo biochemical analysis of biosynthetic enzymes, directed and random approaches toward enzyme engineering, chemoenzymatic synthesis, accessing the biosynthetic potential of uncultured bacteria associated with marine invertebrates, drug discovery Selected Publications: L. Kiang and B. S. Moore, "Characterization of Benzoyl-CoA Biosynthesis Genes in the Enterocin Producing Bacterium Streptomyces maritimus", J.Bacteriol., 185, 399-404 (2003). D. Hoffmann, J. M. Hevel, R. E. Moore, and B. S. Moore, "Sequence Analysis and Biochemical Characterization of the Nostopeptolide A Biosynthetic Gene Cluster from Nostoc sp. GSV224", Gene, 311, 169-178 (2003). L. Xiang and B. S. Moore, "Inactivation, Complementation and Heterologous Expression of encP, a Novel Bacterial Phenylalanine Ammonia-Lyase Encoding Gene", J. Biol. Chem., 277, 32505-32509 (2002). L. Xiang, J. A. Kalaitzis, G. Nilsen, L. Chen, and B. S. Moore, "Mutational Analysis of the Enterocin Favorskii Biosynthetic Rearrangement", Org. Lett., 4, 957-960 (2002). U. Hentschel, J. Hopke, M. Horn, A. B. Friedrich, M. Wagner, J. Hacker, and B. S. Moore, "Molecular Evidence for a Uniform Microbial Community in Sponges from Different Oceans", Appl. Environ. Microbiol., 68, 4431-4440 (2002). B. S. Moore and C. Hertweck, "Biosynthesis and Attachment of Novel Bacterial Polyketide Synthase Starter Units", Nat. Prod. Rep., 19, 70-99 (2002). C. Hertweck, A. P. Jarvis, L. Xiang, B. S. Moore, and N. J. Oldham, "A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid beta-Oxidation", ChemBioChem, 2, 784-786 (2001). B. S. Moore and J. N. Hopke, "Discovery of a New Bacterial Polyketide Biosynthetic Pathway", ChemBioChem, 2, 35-38 (2001). 
Category: Biological Sciences & Engineering
Type: Scientist & Engineers
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